SCOP 1.65: Domain d1lwdb_: 1lwd B:

Lineage for d1lwdb_ (1lwd B:)

1. Root: SCOP 1.65

2. Class c: Alpha and beta proteins (a/b) [51349] (121 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenases [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenases [53659] (2 families)

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins)
   the active site is between the two identical subunits

6. Protein NADP-dependent isocitrate dehydrogenase [82524] (1 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [82525] (1 PDB entry)

8. Domain d1lwdb_: 1lwd B: [78266]
   complexed with ict, mn, so4

Details for d1lwdb_

PDB Entry: 1lwd, 1.85 Å

PDB Description: crystal structure of nadp-dependent isocitrate dehydrogenase from porcine heart mitochondria

SCOP Domain Sequences for d1lwdb_:

Sequence; same for both SEQRES and ATOM records:

>d1lwdb_ c.77.1.1 (B:) NADP-dependent isocitrate dehydrogenase {Pig (Sus scrofa)}
adqrikvakpvvemdgdemtriiwqfikeklilphvdvqlkyfdlglpnrdqtndqvtid
salatqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiicknipr
lvpgwtkpitigrhahgdqykatdfvvdragtfkivftpkdgssakqwevynfpaggvgm
gmyntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifekhyktdfd
kykiwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdg
ktieaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqtle
kvcvetvesgamtkdlagcihglsnvklnehflntsdfldtiksnldralgrq

Timeline for d1lwdb_:

• d1lwdb_ first appeared in SCOP 1.63
  
• d1lwdb_ appears in SCOP 1.67
  
• d1lwdb_ appears in the current release, SCOPe 2.08