SCOP 1.69: Domain d1lwda_: 1lwd A:

Lineage for d1lwda_ (1lwd A:)

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (5 families)
   the constituent families form similar dimers

5. Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins)
   the active site is between the two identical subunits

6. Protein NADP-dependent isocitrate dehydrogenase [82524] (2 species)

7. Species Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)

8. Domain d1lwda_: 1lwd A: [78265]

Details for d1lwda_

PDB Entry: 1lwd, 1.85 Å

PDB Description: crystal structure of nadp-dependent isocitrate dehydrogenase from porcine heart mitochondria

SCOP Domain Sequences for d1lwda_:

Sequence; same for both SEQRES and ATOM records:

>d1lwda_ c.77.1.1 (A:) NADP-dependent isocitrate dehydrogenase {Pig (Sus scrofa)}
adqrikvakpvvemdgdemtriiwqfikeklilphvdvqlkyfdlglpnrdqtndqvtid
salatqkysvavkcatitpdearveefklkkmwkspngtirnilggtvfrepiicknipr
lvpgwtkpitigrhahgdqykatdfvvdragtfkivftpkdgssakqwevynfpaggvgm
gmyntdesisgfahscfqyaiqkkwplymstkntilkaydgrfkdifqeifekhyktdfd
kykiwyehrliddmvaqvlkssggfvwacknydgdvqsdilaqgfgslglmtsvlvcpdg
ktieaeaahgtvtrhyrehqkgrptstnpiasifawtrglehrgkldgnqdlirfaqtle
kvcvetvesgamtkdlagcihglsnvklnehflntsdfldtiksnldralgrq

Timeline for d1lwda_:

• d1lwda_ first appeared in SCOP 1.63
  
• d1lwda_ appears in SCOP 1.67
  
• d1lwda_ appears in SCOP 1.71
  
• d1lwda_ appears in the current release, SCOPe 2.08