SCOP 1.71: Domain d1lwca2: 1lwc A:4-429

Lineage for d1lwca2 (1lwc A:4-429)

1. Root: SCOP 1.71

2. Class e: Multi-domain proteins (alpha and beta) [56572] (48 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (83 PDB entries)

8. Domain d1lwca2: 1lwc A:4-429 [78263]
   Other proteins in same PDB: d1lwca1
   complexed with csd, nvp, po4; mutant

Details for d1lwca2

PDB Entry: 1lwc, 2.62 Å

PDB Description: crystal structure of m184v mutant hiv-1 reverse transcriptase in complex with nevirapine

SCOP Domain Sequences for d1lwca2:

Sequence, based on SEQRES records:

>d1lwca2 e.8.1.2 (A:4-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfai
kkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvplded
frkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqy
vddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqp
ivlpekdswtvndiqklvgklnwasqiypgikvrqlakllrgtkalteviplteeaelel
aenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtn
dvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplv
klwyql

Sequence, based on observed residues (ATOM records):

>d1lwca2 e.8.1.2 (A:4-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfak
lvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkytaftip
sinnpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqyvddlyvgsdlei
gqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvn
diqklvgklnwasqiypgikvrqlakllrgtkalteviplteeaelelaenreilkepvh
gvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqki
ttesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql

Timeline for d1lwca2:

• d1lwca2 first appeared in SCOP 1.63
  
• d1lwca2 appears in SCOP 1.69
  
• d1lwca2 appears in SCOP 1.73
  
• d1lwca2 appears in the current release, SCOPe 2.08