SCOP 1.71: Domain d1lvcb_: 1lvc B:

Lineage for d1lvcb_ (1lvc B:)

1. Root: SCOP 1.71

2. Class e: Multi-domain proteins (alpha and beta) [56572] (48 folds)

3. Fold e.41: Adenylylcyclase toxin (the edema factor) [81299] (1 superfamily)
   3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha

4. Superfamily e.41.1: Adenylylcyclase toxin (the edema factor) [81298] (1 family)
   Domain 1 has topological and active site similarity to the Nucleotidyltransferases (eg. 1kny N-domain); domain 3 binds calmodulin

5. Family e.41.1.1: Adenylylcyclase toxin (the edema factor) [69887] (1 protein)
   decorated with many insertions and the C-terminal domain

6. Protein Adenylylcyclase toxin (the edema factor) [69888] (1 species)

7. Species Bacillus anthracis [TaxId:1392] [69889] (7 PDB entries)

8. Domain d1lvcb_: 1lvc B: [78237]
   Other proteins in same PDB: d1lvcd_, d1lvce_, d1lvcf_

Details for d1lvcb_

PDB Entry: 1lvc, 3.6 Å

PDB Description: crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin and 2' deoxy, 3' anthraniloyl atp

SCOP Domain Sequences for d1lvcb_:

Sequence, based on SEQRES records:

>d1lvcb_ e.41.1.1 (B:) Adenylylcyclase toxin (the edema factor) {Bacillus anthracis}
dvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvhgk
ssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrieel
kengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnwrn
ievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtnll
ikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdnei
fiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitkak
intiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanhifs
qekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksnief
kllykqlnftenetdnfevfqkiid

Sequence, based on observed residues (ATOM records):

>d1lvcb_ e.41.1.1 (B:) Adenylylcyclase toxin (the edema factor) {Bacillus anthracis}
dvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvhgk
ssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrieel
kengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnwrn
ievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnekqkgvtnllik
ygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdneifi
inpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitkakin
tipsvkkiagylsdyynsanhifsqekkrkisifrgiqayneienvlkskqiapeyknyf
qylkeritnqvqlllthqkfkllykqlnftenetdnfevfqkiid

Timeline for d1lvcb_:

• d1lvcb_ first appeared in SCOP 1.63
  
• d1lvcb_ appears in SCOP 1.69
  
• d1lvcb_ appears in SCOP 1.73
  
• d1lvcb_ appears in the current release, SCOPe 2.08