SCOP 1.75: Domain d1lg2a1: 1lg2 A:22-266,A:335-386

Lineage for d1lg2a1 (1lg2 A:22-266,A:335-386)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (14 families)

5. Family c.1.8.5: Type II chitinase [51534] (14 proteins)
   glycosylase family 18

6. Protein Chitotriosidase [82251] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [82252] (10 PDB entries)

8. Domain d1lg2a1: 1lg2 A:22-266,A:335-386 [77950]
   Other proteins in same PDB: d1lg2a2
   complexed with edo

Details for d1lg2a1

PDB Entry: 1lg2, 2.1 Å

PDB Description: crystal structure of human chitotriosidase in complex with ethylene glycol

PDB Compounds: (A:) chitotriosidase

SCOP Domain Sequences for d1lg2a1:

Sequence, based on SEQRES records:

>d1lg2a1 c.1.8.5 (A:22-266,A:335-386) Chitotriosidase {Human (Homo sapiens) [TaxId: 9606]}
aklvcyftnwaqyrqgearflpkdldpslcthliyafagmtnhqlsttewndetlyqefn
glkkmnpklktllaiggwnfgtqkftdmvatannrqtfvnsairflrkysfdgldldwey
pgsqgspavdkerfttlvqdlanafqqeaqtsgkerlllsaavpagqtyvdagyevdkia
qnldfvnlmaydfhgswekvtghnsplykrqeesgaaaslnvdaavqqwlqkgtpaskli
lgmptXddvesfktkvsylkqkglggamvwaldlddfagfscnqgrypliqtlrqels

Sequence, based on observed residues (ATOM records):

>d1lg2a1 c.1.8.5 (A:22-266,A:335-386) Chitotriosidase {Human (Homo sapiens) [TaxId: 9606]}
aklvcyftnwaqyrqgearflpkdldpslcthliyafagmtnhqlsttewndetlyqefn
glkkmnpklktllaiggwnfgtqkftdmvatannrqtfvnsairflrkysfdgldldwey
pgsqgspavdkerfttlvqdlanafqqeaqtsgkerlllsaavpagqtyvdagyevdkia
qnldfvnlmaydfhgswekvtghnsplykraaslnvdaavqqwlqkgtpasklilgmptX
ddvesfktkvsylkqkglggamvwaldlddfagfscnqgrypliqtlrqels

Timeline for d1lg2a1:

• d1lg2a1 first appeared in SCOP 1.63
  
• d1lg2a1 appears in SCOP 1.73
  
• d1lg2a1 appears in SCOPe 2.01
  
• d1lg2a1 appears in the current release, SCOPe 2.08