SCOPe 2.05: Domain d1l2ha_: 1l2h A:

Lineage for d1l2ha_ (1l2h A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.42: beta-Trefoil [50352] (8 superfamilies)
   barrel, closed; n=6, S=12; and a hairpin triplet; meander
   duplication: has internal pseudo threefold symmetry

4. Superfamily b.42.1: Cytokine [50353] (3 families)

5. Family b.42.1.2: Interleukin-1 (IL-1) [50362] (6 proteins)

6. Protein Interleukin-1beta [50363] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50364] (25 PDB entries)
   Uniprot P01584 117-269

8. Domain d1l2ha_: 1l2h A: [77655]
   mutant

Details for d1l2ha_

PDB Entry: 1l2h, 1.54 Å

PDB Description: crystal structure of interleukin 1-beta f42w/w120f mutant

PDB Compounds: (A:) Interleukin 1-beta

SCOPe Domain Sequences for d1l2ha_:

Sequence, based on SEQRES records:

>d1l2ha_ b.42.1.2 (A:) Interleukin-1beta {Human (Homo sapiens) [TaxId: 9606]}
rslnctlrdsqqkslvmsgpyelkalhlqgqdmeqqvvwsmsfvqgeesndkipvalglk
eknlylscvlkddkptlqlesvdpknypkkkmekrfvfnkieinnklefesaqfpnfyis
tsqaenmpvflggtkggqditdftmqfvs

Sequence, based on observed residues (ATOM records):

>d1l2ha_ b.42.1.2 (A:) Interleukin-1beta {Human (Homo sapiens) [TaxId: 9606]}
rslnctlrdsqqkslvmsgpyelkalhlqgqdmeqqvvwsmsfvqgeesnkipvalglke
knlylscvlkddkptlqlesvdpknypkkkmekrfvfnkieinnklefesaqfpnfyist
sqaenmpvflggqditdftmqfvs

Timeline for d1l2ha_:

• d1l2ha_ first appeared in SCOP 1.63
  
• d1l2ha_ appears in SCOPe 2.04
  
• d1l2ha_ appears in SCOPe 2.06
  
• d1l2ha_ appears in the current release, SCOPe 2.08