SCOP 1.71: Domain d1knub_: 1knu B:

Lineage for d1knub_ (1knu B:)

1. Root: SCOP 1.71

2. Class a: All alpha proteins [46456] (226 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (1 family)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (32 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48525] (12 PDB entries)

8. Domain d1knub_: 1knu B: [77458]
   complexed with ypa

Details for d1knub_

PDB Entry: 1knu, 2.5 Å

PDB Description: ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with a synthetic agonist

SCOP Domain Sequences for d1knub_:

Sequence, based on SEQRES records:

>d1knub_ a.123.1.1 (B:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens)}
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkh
itplqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheii
ytmlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlai
fiaviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqiv
tehvqllqvikktetdmslhpllqeiykd

Sequence, based on observed residues (ATOM records):

>d1knub_ a.123.1.1 (B:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens)}
esadlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkh
itkevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiytmlas
lmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifiavii
lsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivtehvql
lqvikktehpllqeiykd

Timeline for d1knub_:

• d1knub_ first appeared in SCOP 1.63
  
• d1knub_ appears in SCOP 1.69
  
• d1knub_ appears in SCOP 1.73
  
• d1knub_ appears in the current release, SCOPe 2.08