SCOPe 2.06: Domain d1kfai1: 1kfa I:3-121

Lineage for d1kfai1 (1kfa I:3-121)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)

6. Protein Immunoglobulin heavy chain variable domain, VH [88543] (22 species)
   VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species

7. Species Mouse (Mus musculus), cluster 2.1 [TaxId:10090] [88549] (15 PDB entries)
   Uniprot P18527 # HV56_MOUSE Ig heavy chain V region 914; 90% sequence identity

8. Domain d1kfai1: 1kfa I:3-121 [77363]
   Other proteins in same PDB: d1kfah2, d1kfai2, d1kfal1, d1kfal2, d1kfam1, d1kfam2
   part of anti-gibberellin A4 Fab 4-B8(8)/E9; conflict: annotated in PDB as human protein
   complexed with ga4

Details for d1kfai1

PDB Entry: 1kfa, 2.8 Å

PDB Description: Crystal structure of Fab fragment complexed with gibberellin A4

PDB Compounds: (I:) monoclonal antibody heavy chain

SCOPe Domain Sequences for d1kfai1:

Sequence; same for both SEQRES and ATOM records:

>d1kfai1 b.1.1.1 (I:3-121) Immunoglobulin heavy chain variable domain, VH {Mouse (Mus musculus), cluster 2.1 [TaxId: 10090]}
mlvesggglvkpggslklscaasgftfssyamswvrqtperrlewvatittrgytfypds
vkgrftvsrdnarntlnlqmsslrsedtamfyctregllldyftmdywgqgtsvtvss

Timeline for d1kfai1:

• d1kfai1 first appeared in SCOP 1.63
  
• d1kfai1 appears in SCOPe 2.05
  
• d1kfai1 appears in SCOPe 2.07
  
• d1kfai1 appears in the current release, SCOPe 2.08