SCOPe 2.04: Domain d1k4ta2: 1k4t A:431-640,A:713-765

Lineage for d1k4ta2 (1k4t A:431-640,A:713-765)

1. Root: SCOPe 2.04

2. Class d: Alpha and beta proteins (a+b) [53931] (380 folds)

3. Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
   core: alpha3-beta3-alpha4; one side of beta-sheet is exposed

4. Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families)

5. Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56363] (15 PDB entries)
   Uniprot P11387 203-765 ! Uniprot P11387 203-767

8. Domain d1k4ta2: 1k4t A:431-640,A:713-765 [77264]
   Other proteins in same PDB: d1k4ta1, d1k4ta3
   protein/DNA complex; complexed with hg, pg4, ttc, ttg

Details for d1k4ta2

PDB Entry: 1k4t, 2.1 Å

PDB Description: human dna topoisomerase i (70 kda) in complex with the poison topotecan and covalent complex with a 22 base pair dna duplex

PDB Compounds: (A:) DNA topoisomerase I

SCOPe Domain Sequences for d1k4ta2:

Sequence; same for both SEQRES and ATOM records:

>d1k4ta2 d.163.1.2 (A:431-640,A:713-765) Eukaryotic DNA topoisomerase I, catalytic core {Human (Homo sapiens) [TaxId: 9606]}
pssrikgekdwqkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalrag
nekeegetadtvgccslrvehinlhpeldgqeyvvefdflgkdsiryynkvpvekrvfkn
lqlfmenkqpeddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapde
nipakilsynranravailcnhqrappktfXqialgtsklnyldpritvawckkwgvpie
kiynktqrekfawaidmadedyef

Timeline for d1k4ta2:

• d1k4ta2 first appeared in SCOP 1.63
  
• d1k4ta2 appears in SCOPe 2.03
  
• d1k4ta2 appears in SCOPe 2.05
  
• d1k4ta2 appears in the current release, SCOPe 2.08