SCOP 1.65: Domain d1k4sa1: 1k4s A:431-632,A:708-765

Lineage for d1k4sa1 (1k4s A:431-632,A:708-765)

1. Root: SCOP 1.65

2. Class d: Alpha and beta proteins (a+b) [53931] (234 folds)

3. Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
   core: alpha3-beta3-alpha4; one side of beta-sheet is exposed

4. Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families)

5. Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)

6. Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [56363] (8 PDB entries)

8. Domain d1k4sa1: 1k4s A:431-632,A:708-765 [77261]
   Other proteins in same PDB: d1k4sa2
   complexed with ido, ptr, spt

Details for d1k4sa1

PDB Entry: 1k4s, 3.2 Å

PDB Description: human dna topoisomerase i in covalent complex with a 22 base pair dna duplex

SCOP Domain Sequences for d1k4sa1:

Sequence; same for both SEQRES and ATOM records:

>d1k4sa1 d.163.1.2 (A:431-632,A:708-765) Eukaryotic DNA topoisomerase I, catalytic core {Human (Homo sapiens)}
pssrikgekdwqkyetarrlkkcvdkirnqyredwkskemkvrqravalyfidklalrag
nekeegetadtvgccslrvehinlhpeldgqeyvvefdflgkdsiryynkvpvekrvfkn
lqlfmenkqpeddlfdrlntgilnkhlqdlmegltakvfrtynasitlqqqlkeltapde
nipakilsynranravailcnhXreenkqialgtsklnyldpritvawckkwgvpiekiy
nktqrekfawaidmadedyef

Timeline for d1k4sa1:

• d1k4sa1 first appeared in SCOP 1.63
  
• d1k4sa1 appears in SCOP 1.67
  
• d1k4sa1 appears in the current release, SCOPe 2.08