SCOPe 2.08: Domain d1itwa_: 1itw A:

Lineage for d1itwa_ (1itw A:)

1. Root: SCOPe 2.08

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.2: Monomeric isocitrate dehydrogenase [82526] (2 proteins)
   the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion
   automatically mapped to Pfam PF03971

6. Protein Monomeric isocitrate dehydrogenase [82527] (1 species)

7. Species Azotobacter vinelandii [TaxId:354] [82528] (1 PDB entry)
   the insert region spans residues 150-404

8. Domain d1itwa_: 1itw A: [76793]
   complexed with ict, mn

Details for d1itwa_

PDB Entry: 1itw, 1.95 Å

PDB Description: crystal structure of the monomeric isocitrate dehydrogenase in complex with isocitrate and mn

PDB Compounds: (A:) isocitrate dehydrogenase

SCOPe Domain Sequences for d1itwa_:

Sequence; same for both SEQRES and ATOM records:

>d1itwa_ c.77.1.2 (A:) Monomeric isocitrate dehydrogenase {Azotobacter vinelandii [TaxId: 354]}
stpkiiytltdeapalatysllpiikaftgssgiavetrdislagrliatfpeyltdtqk
isddlaelgklattpdaniiklpnisasvpqlkaaikelqqqgyklpdypeepktdtekd
vkarydkikgsavnpvlregnsdrraplsvknyarkhphkmgawsadskshvahmdngdf
ygsekaaligapgsvkieliakdgsstvlkaktsvqageiidssvmsknalrnfiaaeie
dakkqgvllsvhlkatmmkvsdpimfgqivsefykdaltkhaevlkqigfdvnngigdly
ariktlpeakqkeieadiqavyaqrpqlamvnsdkgitnlhvpsdvivdasmpamirdsg
kmwgpdgklhdtkavipdrcyagvyqvviedckqhgafdpttmgsvpnvglmaqkaeeyg
shdktfqipadgvvrvtdesgkllleqsveagdiwrmcqakdapiqdwvklavnraratn
tpavfwldparahdaqviakverylkdydtsgldirilspveatrfslariregkdtisv
tgnvlrdyltdlfpimelgtsakmlsivplmsggglfetgaggsapkhvqqfleegylrw
dslgeflalaaslehlgnayknpkalvlastldqatgkildnnksparkvgeidnrgshf
ylalywaqalaaqtedkelqaqftgiakaltdnetkivgelaaaqgkpvdiagyyhpntd
ltskamrpsatfnaalapla

Timeline for d1itwa_:

• d1itwa_ first appeared in SCOP 1.63
  
• d1itwa_ appears in SCOPe 2.07