SCOPe 2.08: Domain d1h25c1: 1h25 C:1-293

Lineage for d1h25c1 (1h25 C:1-293)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (417 PDB entries)
   Uniprot P24941

8. Domain d1h25c1: 1h25 C:1-293 [76525]
   Other proteins in same PDB: d1h25a2, d1h25b1, d1h25b2, d1h25c2, d1h25d1, d1h25d2
   complex with cyclin and an 11-residue recruitment peptide from retinoblastoma-associated protein

Details for d1h25c1

PDB Entry: 1h25, 2.5 Å

PDB Description: cdk2/cyclin a in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein

PDB Compounds: (C:) Cell division protein kinase 2

SCOPe Domain Sequences for d1h25c1:

Sequence, based on SEQRES records:

>d1h25c1 d.144.1.7 (C:1-293) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpv

Sequence, based on observed residues (ATOM records):

>d1h25c1 d.144.1.7 (C:1-293) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdvvppl
dedgrsllsqmlhydpnkrisakaalahpffqdvtkpv

Timeline for d1h25c1:

• d1h25c1 first appeared in SCOP 1.63, called d1h25c_
  
• d1h25c1 appears in SCOPe 2.07