SCOPe 2.05: Family c.43.1.2: NRPS condensation domain (amide synthase)

Lineage for Family c.43.1.2: NRPS condensation domain (amide synthase)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.43: CoA-dependent acyltransferases [52776] (1 superfamily)
   core: 2 layers, a/b; mixed beta-sheet of 6 strands, order 324561; strands 3 & 6 are antiparallel to the rest

4. Superfamily c.43.1: CoA-dependent acyltransferases [52777] (4 families)

5. Family c.43.1.2: NRPS condensation domain (amide synthase) [75229] (2 proteins)
   Pfam PF00668; functional domain of multifunctional enzyme containing tandem repeat of two CAT subunit-like domains

Proteins:

1. Polyketide synthase associated protein 5, PapA5 [110593] (1 species)

   • Species Mycobacterium tuberculosis [TaxId:1773] [110594] (1 PDB entry)
     Uniprot P96208

2. VibH [75230] (1 species)
   relative spatial position of the domains is similar to the monomers in CAT trimer

   • Species Vibrio cholerae [TaxId:666] [75231] (1 PDB entry)

More info for Family c.43.1.2: NRPS condensation domain (amide synthase)

Timeline for Family c.43.1.2: NRPS condensation domain (amide synthase):

• Family c.43.1.2: NRPS condensation domain (amide synthase) first appeared in SCOP 1.61
  
• Family c.43.1.2: NRPS condensation domain (amide synthase) appears in SCOPe 2.04
  
• Family c.43.1.2: NRPS condensation domain (amide synthase) appears in SCOPe 2.06
  
• Family c.43.1.2: NRPS condensation domain (amide synthase) appears in the current release, SCOPe 2.08