Lineage for Protein: Pyruvate dehydrogenase E1 component, PP and Pyr modules
- Root: SCOP 1.63
Class c: Alpha and beta proteins (a/b) [51349] (117 folds) 
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (4 families) 
both pyridine (Pyr)- and pyrophosphate (PP)-binding modules have this fold
conserved core consists of two Pyr and two PP-modules and binds two coenzyme molecules
Family c.36.1.2: TK-like THDP-binding domains [52528] (2 proteins)
different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain
Protein Pyruvate dehydrogenase E1 component, PP and Pyr modules [75185] (1 species)
E1A and E1B fused together in a single-chain protein
Species:
Escherichia coli [TaxId:562] [75186] (1 PDB entry) - Domains for 1l8a:
Domain d1l8aa1: 1l8a A:56-470 [73677]
Other proteins in same PDB: d1l8aa3, d1l8ab3
Domain d1l8aa2: 1l8a A:471-700 [73678]
Other proteins in same PDB: d1l8aa3, d1l8ab3
Domain d1l8ab1: 1l8a B:56-470 [73680]
Other proteins in same PDB: d1l8aa3, d1l8ab3
Domain d1l8ab2: 1l8a B:471-700 [73681]
Other proteins in same PDB: d1l8aa3, d1l8ab3
complexed with mg, tdp
- Domains for 1l8a:
More info for Protein Pyruvate dehydrogenase E1 component, PP and Pyr modules from c.36.1.2: TK-like THDP-binding domains
Timeline for Protein Pyruvate dehydrogenase E1 component, PP and Pyr modules from c.36.1.2: TK-like THDP-binding domains:
- Protein Pyruvate dehydrogenase E1 component, PP and Pyr modules from c.36.1.2: TK-like THDP-binding domains first appeared in SCOP 1.61, called Protein Pyruvate dehydrogenase E1 component from c.36.1.2: TK-like
- Protein Pyruvate dehydrogenase E1 component, PP and Pyr modules from c.36.1.2: TK-like THDP-binding domains does not appear in SCOP 1.65