SCOP 1.67: Domain d1m4ha_: 1m4h A:

Lineage for d1m4ha_ (1m4h A:)

1. Root: SCOP 1.67

2. Class b: All beta proteins [48724] (141 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (2 families)

5. Family b.50.1.2: Pepsin-like [50646] (9 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (3 PDB entries)

8. Domain d1m4ha_: 1m4h A: [74455]

Details for d1m4ha_

PDB Entry: 1m4h, 2.1 Å

PDB Description: crystal structure of beta-secretase complexed with inhibitor om00-3

SCOP Domain Sequences for d1m4ha_:

Sequence; same for both SEQRES and ATOM records:

>d1m4ha_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens)}
rrgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqr
qlsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsn
wegilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsm
iiggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnl
rlpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnq
sfritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigf
avsachvhdefrtaavegpfvtldmedcgyn

Timeline for d1m4ha_:

• d1m4ha_ first appeared in SCOP 1.61
  
• d1m4ha_ appears in SCOP 1.65
  
• d1m4ha_ appears in SCOP 1.69
  
• d1m4ha_ appears in the current release, SCOPe 2.08