SCOPe 2.03: Domain d1m49b_: 1m49 B:

Lineage for d1m49b_ (1m49 B:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Interleukin-2 (IL-2) [47301] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47302] (15 PDB entries)

8. Domain d1m49b_: 1m49 B: [74446]
   complexed with cmm

Details for d1m49b_

PDB Entry: 1m49, 2 Å

PDB Description: crystal structure of human interleukin-2 complexed with sp-1985

PDB Compounds: (B:) interleukin-2

SCOPe Domain Sequences for d1m49b_:

Sequence, based on SEQRES records:

>d1m49b_ a.26.1.2 (B:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
ssstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeel
kpleevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnrwit
fcqsiistlt

Sequence, based on observed residues (ATOM records):

>d1m49b_ a.26.1.2 (B:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
ssstkktqlqlehllldlqmilnginpkltrmltfkfympkkatelkhlqcleeelkple
evlnlaqsrprdlisninvivlelktfmceyadetativeflnrwitfcqsiistlt

Timeline for d1m49b_:

• d1m49b_ first appeared in SCOP 1.61
  
• d1m49b_ appears in SCOPe 2.02
  
• d1m49b_ appears in SCOPe 2.04
  
• d1m49b_ appears in the current release, SCOPe 2.08