SCOPe 2.05: Domain d1m48a_: 1m48 A:

Lineage for d1m48a_ (1m48 A:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Interleukin-2 (IL-2) [47301] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47302] (16 PDB entries)

8. Domain d1m48a_: 1m48 A: [74443]
   complexed with frg

Details for d1m48a_

PDB Entry: 1m48, 1.95 Å

PDB Description: crystal structure of human il-2 complexed with (r)-n-[2-[1- (aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-l- phenylalanine methyl ester

PDB Compounds: (A:) interleukin-2

SCOPe Domain Sequences for d1m48a_:

Sequence, based on SEQRES records:

>d1m48a_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
ssstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeel
kpleevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnrwit
fcqsiistl

Sequence, based on observed residues (ATOM records):

>d1m48a_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
ssstkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeel
kpleevlnlaqrprdlisninvivlelkgsettfmceyadetativeflnrwitfcqsii
stl

Timeline for d1m48a_:

• d1m48a_ first appeared in SCOP 1.61
  
• d1m48a_ appears in SCOPe 2.04
  
• d1m48a_ appears in SCOPe 2.06
  
• d1m48a_ appears in the current release, SCOPe 2.08