SCOPe 2.07: Domain d1m47a_: 1m47 A:

Lineage for d1m47a_ (1m47 A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.2: Short-chain cytokines [47286] (14 proteins)

6. Protein Interleukin-2 (IL-2) [47301] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47302] (19 PDB entries)

8. Domain d1m47a_: 1m47 A: [74442]
   complexed with so4

Details for d1m47a_

PDB Entry: 1m47, 1.99 Å

PDB Description: crystal structure of human interleukin-2

PDB Compounds: (A:) interleukin-2

SCOPe Domain Sequences for d1m47a_:

Sequence, based on SEQRES records:

>d1m47a_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
stkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelkp
leevlnlaqsknfhlrprdlisninvivlelkgsettfmceyadetativeflnrwitfc
qsiistlt

Sequence, based on observed residues (ATOM records):

>d1m47a_ a.26.1.2 (A:) Interleukin-2 (IL-2) {Human (Homo sapiens) [TaxId: 9606]}
stkktqlqlehllldlqmilnginnyknpkltrmltfkfympkkatelkhlqcleeelkp
leevlnlaqnfhlrprdlisninvivlelkgfmceyadetativeflnrwitfcqsiist
lt

Timeline for d1m47a_:

• d1m47a_ first appeared in SCOP 1.61
  
• d1m47a_ appears in SCOPe 2.06
  
• d1m47a_ appears in the current release, SCOPe 2.08