SCOPe 2.06: Domain d1ly3a_: 1ly3 A:

Lineage for d1ly3a_ (1ly3 A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (25 PDB entries)

8. Domain d1ly3a_: 1ly3 A: [74337]
   complexed with cog, nap

Details for d1ly3a_

PDB Entry: 1ly3, 1.9 Å

PDB Description: analysis of quinazoline and pyridopyrimidine n9-c10 reversed bridge antifolates in complex with nadp+ and pneumocystis carinii dihydrofolate reductase

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d1ly3a_:

Sequence; same for both SEQRES and ATOM records:

>d1ly3a_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Fungus (Pneumocystis carinii) [TaxId: 4754]}
mnqqksltlivalttsygigrsnslpwklkkeisyfkrvtsfvptfdsfesmnvvlmgrk
twesiplqfrplkgrinvvitrnesldlgngihsaksldhalellyrtygsessvqinri
fviggaqlykaamdhpkldrimatiiykdihcdvffplkfrdkewssvwkkekhsdlesw
vgtkvphgkinedgfdyefemwtrdl

Timeline for d1ly3a_:

• d1ly3a_ first appeared in SCOP 1.61
  
• d1ly3a_ appears in SCOPe 2.05
  
• d1ly3a_ appears in SCOPe 2.07
  
• d1ly3a_ appears in the current release, SCOPe 2.08