Lineage for d1lqsl_ (1lqs L:)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1991436Fold a.26: 4-helical cytokines [47265] (1 superfamily)
    core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
  4. 1991437Superfamily a.26.1: 4-helical cytokines [47266] (4 families) (S)
    there are two different topoisomers of this fold with different entanglements of the two crossover connections
  5. 1991729Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 protein domains)
    contains an additional helix in one of the crossover connections
  6. 1991795Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species)
    intertwined dimer, similar to interferon-gamma
  7. 1991808Species Human herpesvirus 5 [TaxId:10359] [74708] (1 PDB entry)
  8. 1991809Domain d1lqsl_: 1lqs L: [74192]
    Other proteins in same PDB: d1lqsr1, d1lqsr2, d1lqss1, d1lqss2
    complexed with nag

Details for d1lqsl_

PDB Entry: 1lqs (more details), 2.7 Å

PDB Description: crystal structure of human cytomegalovirus il-10 bound to soluble human il-10r1
PDB Compounds: (L:) interleukin-10-like protein

SCOPe Domain Sequences for d1lqsl_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1lqsl_ a.26.1.3 (L:) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human herpesvirus 5 [TaxId: 10359]}

SCOPe Domain Coordinates for d1lqsl_:

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(The format of our PDB-style files is described here.)

Timeline for d1lqsl_: