Class a: All alpha proteins [46456] (290 folds) |
Fold a.26: 4-helical cytokines [47265] (1 superfamily) core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections |
Superfamily a.26.1: 4-helical cytokines [47266] (4 families) there are two different topoisomers of this fold with different entanglements of the two crossover connections |
Family a.26.1.3: Interferons/interleukin-10 (IL-10) [47305] (9 proteins) contains an additional helix in one of the crossover connections |
Protein Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) [47306] (3 species) intertwined dimer, similar to interferon-gamma |
Species Human (Homo sapiens) [TaxId:9606] [47307] (6 PDB entries) |
Domain d1lk3b_: 1lk3 B: [73951] Other proteins in same PDB: d1lk3h1, d1lk3h2, d1lk3i1, d1lk3i2, d1lk3l1, d1lk3l2, d1lk3m1, d1lk3m2 |
PDB Entry: 1lk3 (more details), 1.91 Å
SCOPe Domain Sequences for d1lk3b_:
Sequence, based on SEQRES records: (download)
>d1lk3b_ a.26.1.3 (B:) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens) [TaxId: 9606]} nmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqfyleevmpqa enqdpdikahvnslgenlktlrlrlrrchrflpcengggsggkskaveqvknafnklqek giykamsefdifinyieaymtmk
>d1lk3b_ a.26.1.3 (B:) Interleukin-10 (cytokine synthesis inhibitory factor, CSIF) {Human (Homo sapiens) [TaxId: 9606]} nmlrdlrdafsrvktffqmkdqldnlllkeslledfkgylgcqalsemiqfyleevmpqa enqdpdikahvnslgenlktlrlrlrrchrflpcekskaveqvknafnklqekgiykams efdifinyieaymtmk
Timeline for d1lk3b_: