SCOP 1.73: Domain d1lewa_: 1lew A:

Lineage for d1lewa_ (1lew A:)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Mouse (Mus musculus) [TaxId:10090] [56131] (3 PDB entries)

8. Domain d1lewa_: 1lew A: [73875]

Details for d1lewa_

PDB Entry: 1lew, 2.3 Å

PDB Description: crystal structure of map kinase p38 complexed to the docking site on its nuclear substrate mef2a

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOP Domain Sequences for d1lewa_:

Sequence, based on SEQRES records:

>d1lewa_ d.144.1.7 (A:) MAP kinase p38 {Mouse (Mus musculus) [TaxId: 10090]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppld

Sequence, based on observed residues (ATOM records):

>d1lewa_ d.144.1.7 (A:) MAP kinase p38 {Mouse (Mus musculus) [TaxId: 10090]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarvatrwyrapei
mlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkisse
sarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyhd
pddepvadpydqsfesrdllidewksltydevisfvpppld

Timeline for d1lewa_:

• d1lewa_ first appeared in SCOP 1.61
  
• d1lewa_ appears in SCOP 1.71
  
• d1lewa_ appears in SCOP 1.75
  
• d1lewa_ appears in the current release, SCOPe 2.08