SCOP 1.63: Domain d1l8aa1: 1l8a A:56-470

Lineage for d1l8aa1 (1l8a A:56-470)

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465

4. Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (4 families)
   both pyridine (Pyr)- and pyrophosphate (PP)-binding modules have this fold
   conserved core consists of two Pyr and two PP-modules and binds two coenzyme molecules

5. Family c.36.1.2: TK-like THDP-binding domains [52528] (2 proteins)
   different order of the modules, PP module is N-terminal, Pyr module is next to it followed by a Rossmann-like domain

6. Protein Pyruvate dehydrogenase E1 component, PP and Pyr modules [75185] (1 species)
   E1A and E1B fused together in a single-chain protein

7. Species Escherichia coli [TaxId:562] [75186] (1 PDB entry)

8. Domain d1l8aa1: 1l8a A:56-470 [73677]
   Other proteins in same PDB: d1l8aa3, d1l8ab3

Details for d1l8aa1

PDB Entry: 1l8a, 1.85 Å

PDB Description: e. coli pyruvate dehydrogenase

SCOP Domain Sequences for d1l8aa1:

Sequence, based on SEQRES records:

>d1l8aa1 c.36.1.2 (A:56-470) Pyruvate dehydrogenase E1 component, PP and Pyr modules {Escherichia coli}
isnyintipveeqpeypgnlelerrirsairwnaimtvlraskkdlelgghmasfqssat
iydvcfnhffrarneqdggdlvyfqghispgvyaraflegrltqeqldnfrqevhgngls
syphpklmpefwqfptvsmglgpigaiyqakflkylehrglkdtskqtvyaflgdgemde
peskgaitiatrekldnlvfvincnlqrldgpvtgngkiinelegifegagwnvikvmwg
srwdellrkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeq
iwalnrgghdpkkiyaafkkaqetkgkatvilahtikgygmgdaaegkniahqvkkmnmd
gvrhirdrfnvpvsdadieklpyitfpegseehtylhaqrqklhgylpsrqpnft

Sequence, based on observed residues (ATOM records):

>d1l8aa1 c.36.1.2 (A:56-470) Pyruvate dehydrogenase E1 component, PP and Pyr modules {Escherichia coli}
isnyintipveeqpeypgnlelerrirsairwnaimtvlraskkdlelgghmasfqssat
iydvcfnhffrarneqdggdlvyfqghispgvyaraflegrltqeqldnfrqevhgngls
syphpklmpefwqfptvsmglgpigaiyqakflkylehrglkdtskqtvyaflgdgemde
peskgaitiatrekldnlvfvincnlqrldgpvtgngkiinelegifegagwnvikvmwg
srwdellrkdtsgkliqlmnetvdgdyqtfkskdgayvrehffgkypetaalvadwtdeq
iwalnrgghdpkkiyaafkkaqetkgkatvilahtikgygmgdaamdgvrhirdrfnvpv
sdadieklpyitfpegseehtylhaqrqklhgylpsrqpnft

Timeline for d1l8aa1:

• d1l8aa1 first appeared in SCOP 1.61
  
• d1l8aa1 appears in SCOP 1.65
  
• d1l8aa1 appears in the current release, SCOPe 2.08