Lineage for d1l7ih1 (1l7i H:1-113)

  1. Root: SCOPe 2.03
  2. 1287432Class b: All beta proteins [48724] (174 folds)
  3. 1287433Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 1287434Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 1287435Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (33 proteins)
  6. 1287638Protein Immunoglobulin heavy chain variable domain, VH [88543] (21 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
  7. 1287642Species Engineered (including hybrid species) [88562] (68 PDB entries)
    SQ NA # humanized antidoby; bactericidal Fab-h6831 ! SQ NA # humanized antibody ! SQ NA # Humanized antibody ! SQ NA # engineered antibody
  8. 1287646Domain d1l7ih1: 1l7i H:1-113 [73656]
    Other proteins in same PDB: d1l7ih2, d1l7il1, d1l7il2
    part of humanized anti-ERBb2 Fab 2C4
    complexed with so4

Details for d1l7ih1

PDB Entry: 1l7i (more details), 1.8 Å

PDB Description: Crystal Structure of the anti-ErbB2 Fab2C4
PDB Compounds: (H:) chimera of Fab2C4: "humanized" murine monoclonal antibody

SCOPe Domain Sequences for d1l7ih1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1l7ih1 b.1.1.1 (H:1-113) Immunoglobulin heavy chain variable domain, VH {Engineered (including hybrid species)}

SCOPe Domain Coordinates for d1l7ih1:

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Timeline for d1l7ih1:

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