SCOPe 2.08: Domain d1kvka1: 1kvk A:1-225

Lineage for d1kvka1 (1kvk A:1-225)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.14: Ribosomal protein S5 domain 2-like [54210] (1 superfamily)
   core: beta(3)-alpha-beta-alpha; 2 layers: alpha/beta; left-handed crossover

4. Superfamily d.14.1: Ribosomal protein S5 domain 2-like [54211] (13 families)

5. Family d.14.1.5: GHMP Kinase, N-terminal domain [54232] (7 proteins)

6. Protein Mevalonate kinase [75353] (3 species)

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [75355] (2 PDB entries)

8. Domain d1kvka1: 1kvk A:1-225 [73060]
   Other proteins in same PDB: d1kvka2
   complexed with atp, mg

Details for d1kvka1

PDB Entry: 1kvk, 2.4 Å

PDB Description: the structure of binary complex between a mammalian mevalonate kinase and atp: insights into the reaction mechanism and human inherited disease

PDB Compounds: (A:) Mevalonate Kinase

SCOPe Domain Sequences for d1kvka1:

Sequence, based on SEQRES records:

>d1kvka1 d.14.1.5 (A:1-225) Mevalonate kinase {Norway rat (Rattus norvegicus) [TaxId: 10116]}
mlsevllvsapgkvilhgehavvhgkvalavalnlrtflvlrpqsngkvslnlpnvgikq
vwdvatlqlldtgfleqgdvpaptleqleklkkvaglprdcvgneglsllaflylylaic
rkqrtlpsldimvwselppgaglgssaaysvcvaaalltaceevtnplkdrgsigswpee
dlksinkwayegervihgnpsgvdnsvstwggalryqqgkmsslk

Sequence, based on observed residues (ATOM records):

>d1kvka1 d.14.1.5 (A:1-225) Mevalonate kinase {Norway rat (Rattus norvegicus) [TaxId: 10116]}
mlsevllvsapgkvilhgehavvhgkvalavalnlrtflvlrpqsngkvslnlpnvgikq
vwdvatlqlldteklkkvaglprdcvgneglsllaflylylaicrkqrtlpsldimvwse
lppgaglgssaaysvcvaaalltaceevtnplkdrgsigswpeedlksinkwayegervi
hgnpsgvdnsvstwggalryqqgkmsslk

Timeline for d1kvka1:

• d1kvka1 first appeared in SCOP 1.61
  
• d1kvka1 appears in SCOPe 2.07