Lineage for d1kmva_ (1kmv A:)

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 843142Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 843143Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families) (S)
  5. 843144Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)
  6. 843259Protein Dihydrofolate reductases, eukaryotic type [53605] (4 species)
  7. 843284Species Human (Homo sapiens) [TaxId:9606] [53607] (25 PDB entries)
  8. 843285Domain d1kmva_: 1kmv A: [72757]
    complexed with dms, lii, ndp, sul

Details for d1kmva_

PDB Entry: 1kmv (more details), 1.05 Å

PDB Description: human dihydrofolate reductase complexed with nadph and (z)-6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5-methylpyrido[2,3-d]pyrimidine (sri-9662), a lipophilic antifolate
PDB Compounds: (A:) dihydrofolate reductase

SCOP Domain Sequences for d1kmva_:

Sequence; same for both SEQRES and ATOM records: (download)

>d1kmva_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

SCOP Domain Coordinates for d1kmva_:

Click to download the PDB-style file with coordinates for d1kmva_.
(The format of our PDB-style files is described here.)

Timeline for d1kmva_: