SCOPe 2.05: Domain d1k8ca_: 1k8c A:

Lineage for d1k8ca_ (1k8c A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Xylose reductase [75058] (1 species)

7. Species Fungus (Candida tenuis) [TaxId:45596] [75059] (8 PDB entries)
   Uniprot O74237

8. Domain d1k8ca_: 1k8c A: [72172]
   complexed with nap

Details for d1k8ca_

PDB Entry: 1k8c, 2.1 Å

PDB Description: Crystal structure of dimeric xylose reductase in complex with NADP(H)

PDB Compounds: (A:) xylose reductase

SCOPe Domain Sequences for d1k8ca_:

Sequence, based on SEQRES records:

>d1k8ca_ c.1.7.1 (A:) Xylose reductase {Fungus (Candida tenuis) [TaxId: 45596]}
sipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgdgvk
raideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafkfvp
ieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldllrga
tikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvemnqgralntptlfahd
tikaiaakynktpaevllrwaaqrgiavipksnlperlvqnrsfntfdltkedfeeiakl
diglrfndpwdwdnipifv

Sequence, based on observed residues (ATOM records):

>d1k8ca_ c.1.7.1 (A:) Xylose reductase {Fungus (Candida tenuis) [TaxId: 45596]}
sipdiklssghlmpsigfgcwklanatageqvyqaikagyrlfdgaedygnekevgdgvk
raideglvkreeifltsklwnnyhdpknvetalnktladlkvdyvdlflihfpiafkfvp
ieekyppgfycgdgnnfvyedvpiletwkaleklvaagkiksigvsnfpgallldllrga
tikpavlqvehhpylqqpkliefaqkagvtitayssfgpqsfvnqgralntptlfahdti
kaiaakynktpaevllrwaaqrgiavipksnlperlvqnrsfntfdltkedfeeiakldi
glrfndpwdwdnipifv

Timeline for d1k8ca_:

• d1k8ca_ first appeared in SCOP 1.61
  
• d1k8ca_ appears in SCOPe 2.04
  
• d1k8ca_ appears in SCOPe 2.06
  
• d1k8ca_ appears in the current release, SCOPe 2.08