SCOP 1.75: Domain d1k2cb_: 1k2c B:

Lineage for d1k2cb_ (1k2c B:)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (3 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (8 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (1 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (247 PDB entries)
   Uniprot P35963 57-155
   Uniprot P04587 69-167
   Uniprot P03366 69-167
   Uniprot P03367 69-167
   Uniprot P03368 69-167
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d1k2cb_: 1k2c B: [72009]
   complexed with dcl, nh2, nle; mutant

Details for d1k2cb_

PDB Entry: 1k2c, 2.2 Å

PDB Description: combining mutations in hiv-1 protease to understand mechanisms of resistance

PDB Compounds: (B:) protease retropepsin

SCOP Domain Sequences for d1k2cb_:

Sequence; same for both SEQRES and ATOM records:

>d1k2cb_ b.50.1.1 (B:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwkrplvtikiggqlkealldtgadntvieemslpgrwkpkmiggiggfikvrqyd
qiiieiaghkaigtvlvgptpsniigrnlltqigatlnf

Timeline for d1k2cb_:

• d1k2cb_ first appeared in SCOP 1.61
  
• d1k2cb_ appears in SCOP 1.73
  
• d1k2cb_ appears in SCOPe 2.01
  
• d1k2cb_ appears in the current release, SCOPe 2.08