SCOPe 2.06: Domain d1jqda_: 1jqd A:

Lineage for d1jqda_ (1jqd A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families)

5. Family c.66.1.19: Histamine methyltransferase [75261] (1 protein)

6. Protein Histamine methyltransferase [75262] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [75263] (7 PDB entries)

8. Domain d1jqda_: 1jqd A: [71787]
   complexed with hsm, sah

Details for d1jqda_

PDB Entry: 1jqd, 2.28 Å

PDB Description: crystal structure analysis of human histamine methyltransferase (thr105 polymorphic variant) complexed with adohcy and histamine

PDB Compounds: (A:) Histamine N-methyltransferase

SCOPe Domain Sequences for d1jqda_:

Sequence, based on SEQRES records:

>d1jqda_ c.66.1.19 (A:) Histamine methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
mrslfsdhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggag
eidlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyq
srmlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwk
kygsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdfl
tetcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

Sequence, based on observed residues (ATOM records):

>d1jqda_ c.66.1.19 (A:) Histamine methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
mrslfhgkyvesfrrflnhstehqcmqefmdkklpgiigrigdtkseikilsigggagei
dlqilskvqaqypgvcinnevvepsaeqiakykelvaktsnlenvkfawhketsseyqsr
mlekkelqkwdfihmiqmlyyvkdipatlkffhsllgtnakmliivvsgssgwdklwkky
gsrfpqddlcqyitsddltqmldnlglkyecydllstmdisdcfidgnengdllwdflte
tcnfnatappdlraelgkdlqepefsakkegkvlfnntlsfiviea

Timeline for d1jqda_:

• d1jqda_ first appeared in SCOP 1.61
  
• d1jqda_ appears in SCOPe 2.05
  
• d1jqda_ appears in SCOPe 2.07
  
• d1jqda_ appears in the current release, SCOPe 2.08