SCOPe 2.08: Domain d1h4la_: 1h4l A:

Lineage for d1h4la_ (1h4l A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK5 [88857] (1 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88858] (5 PDB entries)
   Uniprot Q00535

8. Domain d1h4la_: 1h4l A: [70871]
   Other proteins in same PDB: d1h4ld_, d1h4le_

Details for d1h4la_

PDB Entry: 1h4l, 2.65 Å

PDB Description: structure and regulation of the cdk5-p25(nck5a) complex

PDB Compounds: (A:) cell division protein kinase 5

SCOPe Domain Sequences for d1h4la_:

Sequence, based on SEQRES records:

>d1h4la_ d.144.1.7 (A:) Cyclin-dependent PK, CDK5 {Human (Homo sapiens) [TaxId: 9606]}
qkyeklekigegtygtvfkaknretheivalkrvrlddddegvpssalreicllkelkhk
nivrlhdvlhsdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsrn
vlhrdlkpqnllinrngelkladfglarafgipvrcysaevvtlwyrppdvlfgaklyst
sidmwsagcifaelanaarplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpypm
ypattslvnvvpklnatgrdllqnllkcnpvqrisaeealqhpyfs

Sequence, based on observed residues (ATOM records):

>d1h4la_ d.144.1.7 (A:) Cyclin-dependent PK, CDK5 {Human (Homo sapiens) [TaxId: 9606]}
qkyeklekiygtvfkaknretheivalkrvrldgvpssalreicllkelkhknivrlhdv
lhsdkkltlvfefcdqdlkkyfdscngdldpeivksflfqllkglgfchsrnvlhrdlkp
qnllinrngelkladfglarafgipvrcysaevvtlwyrppdvlfgaklystsidmwsag
cifaelanaarplfpgndvddqlkrifrllgtpteeqwpsmtklpdykpypmypattslv
nvvpklnatgrdllqnllkcnpvqrisaeealqhpyfs

Timeline for d1h4la_:

• d1h4la_ first appeared in SCOP 1.61
  
• d1h4la_ appears in SCOPe 2.07