Lineage for Protein: E1-beta subunit of pyruvate dehydrogenase, Pyr module
- Root: SCOPe 2.01
Class c: Alpha and beta proteins (a/b) [51349] (147 folds) 
Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (8 families) 
there are two different functional modules of this fold: pyridine-binding (Pyr) and pyrophosphate-binding (PP) modules
two Pyr and two PP modules assemble together in a conserved heterotetrameric core that binds two THDP coenzyme molecules
Family c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module [88741] (4 proteins)
parent family to TK and PFOR
heterodimeric protein related to TK; alpha-subunit is the PP module and the N-terminal domain of beta-subunit is the Pyr module
Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module [69472] (2 species)
Species:
Human (Homo sapiens) [TaxId:9606] [89653] (2 PDB entries) - Domains for 1ni4:
Domain d1ni4b1: 1ni4 B:0-191 [85729]
Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2
complexed with k, mg, tpp
Domain d1ni4d1: 1ni4 D:0-191 [85732]
Other proteins in same PDB: d1ni4a_, d1ni4b2, d1ni4c_, d1ni4d2
complexed with k, mg, tpp
- Domains for 2ozl:
Domain d2ozlb1: 2ozl B:0-191 [139447]
Other proteins in same PDB: d2ozla1, d2ozlb2, d2ozlc_, d2ozld2
automatically matched to d1ni4b1
complexed with k, mg, tpp
Domain d2ozld1: 2ozl D:0-191 [139449]
Other proteins in same PDB: d2ozla1, d2ozlb2, d2ozlc_, d2ozld2
automatically matched to d1ni4b1
complexed with k, mg, tpp
- Domains for 1ni4:
Pyrobaculum aerophilum [TaxId:13773] [69473] (1 PDB entry) - Domain for 1ik6:
Domain d1ik6a1: 1ik6 A:1-191 [66174]
Other proteins in same PDB: d1ik6a2
structure determined on its own rather in the complex with E1-alpha
- Domain for 1ik6:
More info for Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module
Timeline for Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module:
- Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module first appeared in SCOP 1.59, called Protein E1-beta subunit of pyruvate dehydrogenase from c.36.1.3: Branched-chain alpha-keto acid dehydrogenase
- Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOP 1.75
- Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in SCOPe 2.02
- Protein E1-beta subunit of pyruvate dehydrogenase, Pyr module from c.36.1.7: Branched-chain alpha-keto acid dehydrogenase Pyr module appears in the current release, SCOPe 2.08