SCOPe 2.08: Protein: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

Lineage for Protein: 1-deoxy-D-xylulose-5-phosphate reductoisomerase

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)
Family c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain [51800] (22 proteins)
family members also share a common alpha+beta fold in C-terminal domain
Protein 1-deoxy-D-xylulose-5-phosphate reductoisomerase [69410] (2 species)

Species:

Escherichia coli [TaxId:562] [69411] (11 PDB entries)
Uniprot P45568

Domains for 1jvs:
1. Domain d1jvsa2: 1jvs A:1-125,A:275-300 [77188]
  Other proteins in same PDB: d1jvsa1, d1jvsa3, d1jvsa4, d1jvsa5, d1jvsb1, d1jvsb3, d1jvsb4
  complexed with ndp, so4
2. Domain d1jvsb2: 1jvs B:1-125,B:275-300 [77191]
  Other proteins in same PDB: d1jvsa1, d1jvsa3, d1jvsa4, d1jvsa5, d1jvsb1, d1jvsb3, d1jvsb4
  complexed with ndp, so4
Domains for 1k5h:
1. Domain d1k5ha2: 1k5h A:1-125,A:275-300 [68193]
  Other proteins in same PDB: d1k5ha1, d1k5ha3, d1k5hb1, d1k5hb3, d1k5hc1, d1k5hc3
2. Domain d1k5hb2: 1k5h B:1-125,B:275-300 [68196]
  Other proteins in same PDB: d1k5ha1, d1k5ha3, d1k5hb1, d1k5hb3, d1k5hc1, d1k5hc3
3. Domain d1k5hc2: 1k5h C:1-125,C:275-300 [68199]
  Other proteins in same PDB: d1k5ha1, d1k5ha3, d1k5hb1, d1k5hb3, d1k5hc1, d1k5hc3
Domains for 1onn:
1. Domain d1onna2: 1onn A:1-125,A:275-300 [87154]
  Other proteins in same PDB: d1onna1, d1onna3, d1onnb1, d1onnb3
2. Domain d1onnb2: 1onn B:1-125,B:275-300 [87157]
  Other proteins in same PDB: d1onna1, d1onna3, d1onnb1, d1onnb3
Domains for 1ono:
1. Domain d1onoa2: 1ono A:1-125,A:275-300 [87160]
  Other proteins in same PDB: d1onoa1, d1onoa3, d1onob1, d1onob3
  complexed with mn
2. Domain d1onob2: 1ono B:1-125,B:275-300 [87163]
  Other proteins in same PDB: d1onoa1, d1onoa3, d1onob1, d1onob3
  complexed with mn
Domains for 1onp:
1. Domain d1onpa2: 1onp A:1-125,A:275-300 [87166]
  Other proteins in same PDB: d1onpa1, d1onpa3, d1onpb1, d1onpb3
  complexed with fom, mn
2. Domain d1onpb2: 1onp B:1-125,B:275-300 [87169]
  Other proteins in same PDB: d1onpa1, d1onpa3, d1onpb1, d1onpb3
  complexed with fom, mn
Domain for 1q0h:
- Domain d1q0ha2: 1q0h A:1-125,A:275-300 [104441]
  Other proteins in same PDB: d1q0ha1, d1q0ha3
  complexed with cit, fom, ndp
Domain for 1q0l:
- Domain d1q0la2: 1q0l A:1-125,A:275-300 [104456]
  Other proteins in same PDB: d1q0la1, d1q0la3
  complexed with fom, ndp
Domains for 1q0q:
1. Domain d1q0qa2: 1q0q A:1-125,A:275-300 [104465]
  Other proteins in same PDB: d1q0qa1, d1q0qa3, d1q0qb1, d1q0qb3
  complexed with dxp, ndp
2. Domain d1q0qb2: 1q0q B:1-125,B:275-300 [104468]
  Other proteins in same PDB: d1q0qa1, d1q0qa3, d1q0qb1, d1q0qb3
  complexed with dxp, ndp

Domains for 1t1r:

Domain d1t1ra2: 1t1r A:1-125 [106263]
Other proteins in same PDB: d1t1ra1, d1t1ra4, d1t1ra5, d1t1rb1, d1t1rb4, d1t1rb5
complexed with imb, so4

Domain d1t1ra3: 1t1r A:275-300 [106264]
Other proteins in same PDB: d1t1ra1, d1t1ra4, d1t1ra5, d1t1rb1, d1t1rb4, d1t1rb5
complexed with imb, so4
fragment; missing more than one-third of the common structure and/or sequence

Domain d1t1rb2: 1t1r B:1-125 [106267]
Other proteins in same PDB: d1t1ra1, d1t1ra4, d1t1ra5, d1t1rb1, d1t1rb4, d1t1rb5
complexed with imb, so4

Domain d1t1rb3: 1t1r B:275-300 [106268]
Other proteins in same PDB: d1t1ra1, d1t1ra4, d1t1ra5, d1t1rb1, d1t1rb4, d1t1rb5
complexed with imb, so4
fragment; missing more than one-third of the common structure and/or sequence

Domains for 1t1s:

Domain d1t1sa2: 1t1s A:1-125 [106271]
Other proteins in same PDB: d1t1sa1, d1t1sa4, d1t1sa5, d1t1sb1, d1t1sb4, d1t1sb5
complexed with cbq, mg, so4

Domain d1t1sa3: 1t1s A:275-300 [106272]
Other proteins in same PDB: d1t1sa1, d1t1sa4, d1t1sa5, d1t1sb1, d1t1sb4, d1t1sb5
complexed with cbq, mg, so4
fragment; missing more than one-third of the common structure and/or sequence

Domain d1t1sb2: 1t1s B:1-125 [106275]
Other proteins in same PDB: d1t1sa1, d1t1sa4, d1t1sa5, d1t1sb1, d1t1sb4, d1t1sb5
complexed with cbq, mg, so4

Domain d1t1sb3: 1t1s B:275-300 [106276]
Other proteins in same PDB: d1t1sa1, d1t1sa4, d1t1sa5, d1t1sb1, d1t1sb4, d1t1sb5
complexed with cbq, mg, so4
fragment; missing more than one-third of the common structure and/or sequence

Domains for 2egh:
1. Domain d2egha2: 2egh A:1-125,A:275-300 [132122]
  Other proteins in same PDB: d2egha1, d2egha3, d2egha4, d2egha5, d2eghb1, d2eghb3, d2eghb4
  automatically matched to d1jvsa2
  complexed with fom, mg, ndp
2. Domain d2eghb2: 2egh B:1-125,B:275-300 [132125]
  Other proteins in same PDB: d2egha1, d2egha3, d2egha4, d2egha5, d2eghb1, d2eghb3, d2eghb4
  automatically matched to d1jvsa2
  complexed with fom, mg, ndp

Zymomonas mobilis [TaxId:542] [110420] (2 PDB entries)
Uniprot Q9X5F2
1. Domains for 1r0k:
  1. Domain d1r0ka2: 1r0k A:3-126,A:265-290 [104724]
    Other proteins in same PDB: d1r0ka1, d1r0ka3, d1r0kb1, d1r0kb3, d1r0kc1, d1r0kc3, d1r0kd1, d1r0kd3
    complexed with act
  2. Domain d1r0kb2: 1r0k B:3-126,B:265-290 [104727]
    Other proteins in same PDB: d1r0ka1, d1r0ka3, d1r0kb1, d1r0kb3, d1r0kc1, d1r0kc3, d1r0kd1, d1r0kd3
    complexed with act
  3. Domain d1r0kc2: 1r0k C:3-126,C:265-290 [104730]
    Other proteins in same PDB: d1r0ka1, d1r0ka3, d1r0kb1, d1r0kb3, d1r0kc1, d1r0kc3, d1r0kd1, d1r0kd3
    complexed with act
  4. Domain d1r0kd2: 1r0k D:3-126,D:265-290 [104733]
    Other proteins in same PDB: d1r0ka1, d1r0ka3, d1r0kb1, d1r0kb3, d1r0kc1, d1r0kc3, d1r0kd1, d1r0kd3
    complexed with act
2. Domains for 1r0l:
  1. Domain d1r0la2: 1r0l A:3-126,A:265-290 [104736]
    Other proteins in same PDB: d1r0la1, d1r0la3, d1r0lb1, d1r0lb3, d1r0lc1, d1r0lc3, d1r0ld1, d1r0ld3
    complexed with ndp
  2. Domain d1r0lb2: 1r0l B:3-126,B:265-290 [104739]
    Other proteins in same PDB: d1r0la1, d1r0la3, d1r0lb1, d1r0lb3, d1r0lc1, d1r0lc3, d1r0ld1, d1r0ld3
    complexed with ndp
  3. Domain d1r0lc2: 1r0l C:3-126,C:265-290 [104742]
    Other proteins in same PDB: d1r0la1, d1r0la3, d1r0lb1, d1r0lb3, d1r0lc1, d1r0lc3, d1r0ld1, d1r0ld3
    complexed with ndp
  4. Domain d1r0ld2: 1r0l D:3-126,D:265-290 [104745]
    Other proteins in same PDB: d1r0la1, d1r0la3, d1r0lb1, d1r0lb3, d1r0lc1, d1r0lc3, d1r0ld1, d1r0ld3
    complexed with ndp

More info for Protein 1-deoxy-D-xylulose-5-phosphate reductoisomerase from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain

Timeline for Protein 1-deoxy-D-xylulose-5-phosphate reductoisomerase from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain:

Protein 1-deoxy-D-xylulose-5-phosphate reductoisomerase from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain first appeared in SCOP 1.59
Protein 1-deoxy-D-xylulose-5-phosphate reductoisomerase from c.2.1.3: Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain appears in SCOPe 2.07