SCOPe 2.06: Domain d1kmcb_: 1kmc B:

Lineage for d1kmcb_ (1kmc B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Caspase-7 [63961] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63962] (12 PDB entries)
   Uniprot P55210 57-303

8. Domain d1kmcb_: 1kmc B: [68691]
   Other proteins in same PDB: d1kmcc_, d1kmcd_
   complexed to the xiap-bir2 fragment (chains C and D)

Details for d1kmcb_

PDB Entry: 1kmc, 2.9 Å

PDB Description: crystal structure of the caspase-7 / xiap-bir2 complex

PDB Compounds: (B:) caspase-7

SCOPe Domain Sequences for d1kmcb_:

Sequence, based on SEQRES records:

>d1kmcb_ c.17.1.1 (B:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
ptyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcs
cakmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktll
ekpklffiqaargtelddgiqadsgpindtdanprykipveadflfaystvpgyyswrsp
grgswfvqalcsileehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsml
tkelyfs

Sequence, based on observed residues (ATOM records):

>d1kmcb_ c.17.1.1 (B:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
ptyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcs
cakmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktll
ekpklffiqaargtelddgiqrykipveadflfaystvpgyyswrspgrgswfvqalcsi
leehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmltkelyfs

Timeline for d1kmcb_:

• d1kmcb_ first appeared in SCOP 1.59
  
• d1kmcb_ appears in SCOPe 2.05
  
• d1kmcb_ appears in SCOPe 2.07
  
• d1kmcb_ appears in the current release, SCOPe 2.08