SCOPe 2.01: Domain d1kmca_: 1kmc A:

Lineage for d1kmca_ (1kmc A:)

1. Root: SCOPe 2.01

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein Caspase-7 [63961] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63962] (9 PDB entries)
   Uniprot P55210 57-303

8. Domain d1kmca_: 1kmc A: [68690]
   Other proteins in same PDB: d1kmcc_, d1kmcd_
   complexed to the xiap-bir2 fragment (chains C and D)

Details for d1kmca_

PDB Entry: 1kmc, 2.9 Å

PDB Description: crystal structure of the caspase-7 / xiap-bir2 complex

PDB Compounds: (A:) caspase-7

SCOPe Domain Sequences for d1kmca_:

Sequence, based on SEQRES records:

>d1kmca_ c.17.1.1 (A:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
tyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcsc
akmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktlle
kpklffiqaargtelddgiqadsgpindtdanprykipveadflfaystvpgyyswrspg
rgswfvqalcsileehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmlt
kelyfsq

Sequence, based on observed residues (ATOM records):

>d1kmca_ c.17.1.1 (A:) Caspase-7 {Human (Homo sapiens) [TaxId: 9606]}
tyqynmnfeklgkciiinnknfdkvtgmgvrngtdkdaealfkcfrslgfdvivyndcsc
akmqdllkkaseedhtnaacfacillshgeenviygkdgvtpikdltahfrgdrcktlle
kpklffiqaargtelddgiqrykipveadflfaystvpgyyswrspgrgswfvqalcsil
eehgkdleimqiltrvndrvarhfesqsddphfhekkqipcvvsmltkelyfsq

Timeline for d1kmca_:

• d1kmca_ first appeared in SCOP 1.59
  
• d1kmca_ appears in SCOP 1.75
  
• d1kmca_ appears in SCOPe 2.02
  
• d1kmca_ appears in the current release, SCOPe 2.08