SCOP 1.75: Domain d1kewb_: 1kew B:

Lineage for d1kewb_ (1kew B:)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein dTDP-glucose 4,6-dehydratase (RmlB) [51755] (4 species)

7. Species Streptococcus suis, serotype 2 [TaxId:1307] [69406] (6 PDB entries)

8. Domain d1kewb_: 1kew B: [68545]
   complexed with gol, nad, tyd

Details for d1kewb_

PDB Entry: 1kew, 1.8 Å

PDB Description: The crystal structure of dTDP-D-glucose 4,6-dehydratase (RmlB) from Salmonella enterica serovar Typhimurium with thymidine diphosphate bound

PDB Compounds: (B:) dtdp-d-glucose 4,6-dehydratase

SCOP Domain Sequences for d1kewb_:

Sequence; same for both SEQRES and ATOM records:

>d1kewb_ c.2.1.2 (B:) dTDP-glucose 4,6-dehydratase (RmlB) {Streptococcus suis, serotype 2 [TaxId: 1307]}
mkilitggagfigsavvrhiikntqdtvvnidkltyagnleslsdisesnrynfehadic
dsaeitrifeqyqpdavmhlaaeshvdrsitgpaafietnivgtyallevarkywsalge
dkknnfrfhhistdevygdlphpdevensvtlplftettayapsspysaskassdhlvra
wrrtyglptivtncsnnygpyhfpekliplvilnalegkplpiygkgdqirdwlyvedha
ralhmvvtegkagetynigghnekknldvvfticdlldeivpkatsyreqityvadrpgh
drryaidagkisrelgwkpletfesgirktvewylantqwvnnvksgayqswieqnyegr
q

Timeline for d1kewb_:

• d1kewb_ first appeared in SCOP 1.59
  
• d1kewb_ appears in SCOP 1.73
  
• d1kewb_ appears in SCOPe 2.01
  
• d1kewb_ appears in the current release, SCOPe 2.08