SCOP 1.75: Domain d1k6xa_: 1k6x A:

Lineage for d1k6xa_ (1k6x A:)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein Negative transcriptional regulator NmrA [69407] (1 species)
   has an UDP-galactose 4-epimerase-like structure but evolved a different function

7. Species Aspergillus nidulans [TaxId:162425] [69408] (8 PDB entries)
   Uniprot O59919

8. Domain d1k6xa_: 1k6x A: [68238]
   complexed with cl, nad

Details for d1k6xa_

PDB Entry: 1k6x, 1.5 Å

PDB Description: Crystal structure of Nmra, a negative transcriptional regulator in complex with NAD at 1.5 A resolution (Trigonal form)

PDB Compounds: (A:) NmrA

SCOP Domain Sequences for d1k6xa_:

Sequence, based on SEQRES records:

>d1k6xa_ c.2.1.2 (A:) Negative transcriptional regulator NmrA {Aspergillus nidulans [TaxId: 162425]}
qqkktiavvnatgrqaaslirvaaavghhvraqvhslkgliaeelqaipnvtlfqgplln
nvplmdtlfegahlafinttsqagdeiaigkdladaakragtiqhyiyssmpdhslygpw
pavpmwapkftvenyvrqlglpstfvyagiynnnftslpyplfqmelmpdgtfewhapfd
pdiplpwldaehdvgpallqifkdgpqkwnghrialtfetlspvqvcaafsralnrrvty
vqvpkveikvnipvgyreqleaievvfgehkapyfplpefsrpaagspkglgpangkgag
agmmqgpggvisqrvtdearklwsgwrdmeeyarevfpieeeangldwml

Sequence, based on observed residues (ATOM records):

>d1k6xa_ c.2.1.2 (A:) Negative transcriptional regulator NmrA {Aspergillus nidulans [TaxId: 162425]}
qqkktiavvnatgrqaaslirvaaavghhvraqvhslkgliaeelqaipnvtlfqgplln
nvplmdtlfegahlafinttsqagdeiaigkdladaakragtiqhyiyssmpdhslygpw
pavpmwapkftvenyvrqlglpstfvyagiynnnftslpyplfqmelmpdgtfewhapfd
pdiplpwldaehdvgpallqifkdgpqkwnghrialtfetlspvqvcaafsralnrrvty
vqvpkveikvnipvgyreqleaievvfgehkapyfplpefsggvisqrvtdearklwsgw
rdmeeyarevfpieeeangldwml

Timeline for d1k6xa_:

• d1k6xa_ first appeared in SCOP 1.59
  
• d1k6xa_ appears in SCOP 1.73
  
• d1k6xa_ appears in SCOPe 2.01
  
• d1k6xa_ appears in the current release, SCOPe 2.08