SCOPe 2.04: Domain d1jvna1: 1jvn A:230-552

Lineage for d1jvna1 (1jvn A:230-552)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.2: Ribulose-phoshate binding barrel [51366] (7 families)

5. Family c.1.2.1: Histidine biosynthesis enzymes [51367] (3 proteins)
   structural evidence for the gene duplication within the barrel fold
   automatically mapped to Pfam PF00977

6. Protein Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF [51370] (4 species)

7. Species Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId:4932] [69379] (4 PDB entries)

8. Domain d1jvna1: 1jvn A:230-552 [67355]
   Other proteins in same PDB: d1jvna2, d1jvnb2
   complexed with ni, pop, so4

Details for d1jvna1

PDB Entry: 1jvn, 2.1 Å

PDB Description: crystal structure of imidazole glycerol phosphate synthase: a tunnel through a (beta/alpha)8 barrel joins two active sites

PDB Compounds: (A:) bifunctional histidine biosynthesis protein hishf

SCOPe Domain Sequences for d1jvna1:

Sequence, based on SEQRES records:

>d1jvna1 c.1.2.1 (A:230-552) Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF {Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId: 4932]}
dysnygltrriiacldvrtndqgdlvvtkgdqydvreksdgkgvrnlgkpvqlaqkyyqq
gadevtflnitsfrdcplkdtpmlevlkqaaktvfvpltvgggikdivdvdgtkipalev
aslyfrsgadkvsigtdavyaaekyyelgnrgdgtspietiskaygaqavvisvdpkrvy
vnsqadtknkvfeteypgpngekycwyqctikggresrdlgvweltracealgageilln
cidkdgsnsgydleliehvkdavkipviassgagvpehfeeaflktradaclgagmfhrg
eftvndvkeyllehglkvrmdee

Sequence, based on observed residues (ATOM records):

>d1jvna1 c.1.2.1 (A:230-552) Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF {Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId: 4932]}
dysnygltrriiacldvrtndqgdlvvtkgdlgkpvqlaqkyyqqgadevtflnitdcpl
kdtpmlevlkqaaktvfvpltvgggikdivdvdgtkipalevaslyfrsgadkvsigtda
vyaaekyyelgnrgdgtspietiskaygaqavvisvdpkrvyvnsqadtknkvfeteypg
pngekycwyqctikggresrdlgvweltracealgageillncidkdgsnsgydlelieh
vkdavkipviassgagvpehfeeaflktradaclgagmfhrgeftvndvkeyllehglkv
rmdee

Timeline for d1jvna1:

• d1jvna1 first appeared in SCOP 1.59
  
• d1jvna1 appears in SCOPe 2.03
  
• d1jvna1 appears in SCOPe 2.05
  
• d1jvna1 appears in the current release, SCOPe 2.08