SCOPe 2.05: Domain d1jsca1: 1jsc A:280-460

Lineage for d1jsca1 (1jsc A:280-460)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain [52475] (8 proteins)
   N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold

6. Protein Acetohydroxyacid synthase catalytic subunit [69463] (2 species)

7. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [69464] (6 PDB entries)
   Uniprot P07342 84-687

8. Domain d1jsca1: 1jsc A:280-460 [67224]
   Other proteins in same PDB: d1jsca2, d1jsca3, d1jscb2, d1jscb3
   complexed with 2hp, fad, k, mg, tpp

Details for d1jsca1

PDB Entry: 1jsc, 2.6 Å

PDB Description: Crystal Structure of the Catalytic Subunit of Yeast Acetohydroxyacid Synthase: A target for Herbicidal Inhibitors

PDB Compounds: (A:) acetohydroxy-acid synthase

SCOPe Domain Sequences for d1jsca1:

Sequence; same for both SEQRES and ATOM records:

>d1jsca1 c.31.1.3 (A:280-460) Acetohydroxyacid synthase catalytic subunit {Baker's yeast (Saccharomyces cerevisiae) [TaxId: 4932]}
aqdefvmqsinkaadlinlakkpvlyvgagilnhadgprllkelsdraqipvtttlqglg
sfdqedpksldmlgmhgcatanlavqnadliiavgarfddrvtgniskfapearraaaeg
rggiihfevspkninkvvqtqiavegdattnlgkmmskifpvkersewfaqinkwkkeyp
y

Timeline for d1jsca1:

• d1jsca1 first appeared in SCOP 1.59
  
• d1jsca1 appears in SCOPe 2.04
  
• d1jsca1 appears in SCOPe 2.06
  
• d1jsca1 appears in the current release, SCOPe 2.08