SCOPe 2.07: Domain d1jpsh2: 1jps H:118-217

Lineage for d1jpsh2 (1jps H:118-217)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (184 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d1jpsh2: 1jps H:118-217 [67046]
   Other proteins in same PDB: d1jpsh1, d1jpsl1, d1jpsl2, d1jpst1, d1jpst2
   part of humanized Fab D3H44 against human tissue factor

Details for d1jpsh2

PDB Entry: 1jps, 1.85 Å

PDB Description: crystal structure of tissue factor in complex with humanized fab d3h44

PDB Compounds: (H:) immunoglobulin Fab D3H44, heavy chain

SCOPe Domain Sequences for d1jpsh2:

Sequence, based on SEQRES records:

>d1jpsh2 b.1.1.2 (H:118-217) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

Sequence, based on observed residues (ATOM records):

>d1jpsh2 b.1.1.2 (H:118-217) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapssggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglys
lssvvtvpssslgtqtyicnvnhkpsntkvdkkvep

Timeline for d1jpsh2:

• d1jpsh2 first appeared in SCOP 1.59
  
• d1jpsh2 appears in SCOPe 2.06
  
• d1jpsh2 appears in the current release, SCOPe 2.08