SCOP 1.67: Domain d1jlea2: 1jle A:1-429

Lineage for d1jlea2 (1jle A:1-429)

1. Root: SCOP 1.67

2. Class e: Multi-domain proteins (alpha and beta) [56572] (40 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (71 PDB entries)

8. Domain d1jlea2: 1jle A:1-429 [66843]
   Other proteins in same PDB: d1jlea1
   mutant

Details for d1jlea2

PDB Entry: 1jle, 2.8 Å

PDB Description: crystal structure of y188c mutant hiv-1 reverse transcriptase

SCOP Domain Sequences for d1jlea2:

Sequence, based on SEQRES records:

>d1jlea2 e.8.1.2 (A:1-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdivi
yqymddlavgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlakllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyql

Sequence, based on observed residues (ATOM records):

>d1jlea2 e.8.1.2 (A:1-429) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1}
pispietvpvklkpgmdgpqwplteekikalveictemekegkiskinpyntpvfklvdf
relnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinn
etpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlavgsdleigq
hrtkieelrqhllrwglttpkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqk
lvgklnwasqiypgikvrqlakllrgtkalteviplteeaelelaenreilkepvhgvyy
dpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittes
iviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyql

Timeline for d1jlea2:

• d1jlea2 first appeared in SCOP 1.59
  
• d1jlea2 appears in SCOP 1.65
  
• d1jlea2 appears in SCOP 1.69
  
• d1jlea2 appears in the current release, SCOPe 2.08