SCOPe 2.03: Domain d1hcfa_: 1hcf A:

Lineage for d1hcfa_ (1hcf A:)

1. Root: SCOPe 2.03

2. Class g: Small proteins [56992] (90 folds)

3. Fold g.17: Cystine-knot cytokines [57500] (1 superfamily)
   disulfide-rich fold; common core is all-beta

4. Superfamily g.17.1: Cystine-knot cytokines [57501] (8 families)

5. Family g.17.1.3: Neurotrophin [57520] (5 proteins)
   automatically mapped to Pfam PF00243

6. Protein Neurotrophin 4, NT4 [57523] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [57524] (3 PDB entries)

8. Domain d1hcfa_: 1hcf A: [65788]
   Other proteins in same PDB: d1hcfx_, d1hcfy_
   homodimer
   complexed with so4

Details for d1hcfa_

PDB Entry: 1hcf, 2.7 Å

PDB Description: crystal structure of trkb-d5 bound to neurotrophin-4/5

PDB Compounds: (A:) neurotrophin-4

SCOPe Domain Sequences for d1hcfa_:

Sequence, based on SEQRES records:

>d1hcfa_ g.17.1.3 (A:) Neurotrophin 4, NT4 {Human (Homo sapiens) [TaxId: 9606]}
gvsetapasrrgelavcdavsgwvtdrrtavdlrgrevevlgevpaaggsplrqyffetr
ckadnaeeggpgaggggcrgvdrrhwvseckakqsyvraltadaqgrvgwrwiridtacv
ctllsrt

Sequence, based on observed residues (ATOM records):

>d1hcfa_ g.17.1.3 (A:) Neurotrophin 4, NT4 {Human (Homo sapiens) [TaxId: 9606]}
gvsetapasrrgelavcdavsgwvtdrrtavdlrgrevevlgevpaaggsplrqyffetr
ckadpgaggggcrgvdrrhwvseckakqsyvraltadaqgrvgwrwiridtacvctllsr
t

Timeline for d1hcfa_:

• d1hcfa_ first appeared in SCOP 1.59
  
• d1hcfa_ appears in SCOPe 2.02
  
• d1hcfa_ appears in SCOPe 2.04
  
• d1hcfa_ appears in the current release, SCOPe 2.08