Lineage for Family c.31.1.5: Sir2 family of transcriptional regulators

  1. Root: SCOP 1.65
  2. 305035Class c: Alpha and beta proteins (a/b) [51349] (121 folds)
  3. 312760Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. 312761Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (5 families) (S)
    binds cofactor molecules in the opposite direction than classical Rossmann fold
  5. 312841Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (3 proteins)
    silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

Proteins:

  1. 312842AF0112, Sir2 homolog (Sir2-AF2) [82380] (1 species)
  2. 312845AF1676, Sir2 homolog (Sir2-AF1?) [63985] (1 species)
  3. 312855Sirt2 histone deacetylase [63987] (1 species)

More info for Family c.31.1.5: Sir2 family of transcriptional regulators

Timeline for Family c.31.1.5: Sir2 family of transcriptional regulators: