Lineage for Family c.31.1.5: Sir2 family of transcriptional regulators

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2107255Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like
  4. 2107256Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families) (S)
    binds cofactor molecules in the opposite direction than classical Rossmann fold
  5. 2107522Family c.31.1.5: Sir2 family of transcriptional regulators [63984] (8 protein domains)
    silent information regulator 2; contains insertion of a rubredoxin-like zinc finger domain

Protein Domains:

  1. 2107523AF0112, Sir2 homolog (Sir2-AF2) [82380] (1 species)
  2. 2107536AF1676, Sir2 homolog (Sir2-AF1?) [63985] (1 species)
  3. 2107546Hst2 [102294] (1 species)
  4. 2107555NAD-dependent deacetylase CobB [102292] (1 species)
  5. 2107558NAD-dependent deacetylase NpdA [142126] (1 species)
  6. 2107568NAD-dependent deacetylase sirtuin-5 [142128] (1 species)
  7. 2107578Sirt2 histone deacetylase [63987] (1 species)
  8. 2107583automated matches [191258] (3 species)
    not a true protein
    1. 2107584Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [225225] (2 PDB entries)
    2. 2107587Species Human (Homo sapiens) [TaxId:9606] [189817] (16 PDB entries)
    3. 2297527Species Danio rerio [TaxId:7955] [340828] (2 PDB entries)

More info for Family c.31.1.5: Sir2 family of transcriptional regulators

Timeline for Family c.31.1.5: Sir2 family of transcriptional regulators: