Lineage for Protein: Type II 3-hydroxyacyl-CoA dehydrogenase

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 819418Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 819419Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) (S)
  5. 819736Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 820673Protein Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)

Species:

  1. 820674Human (Homo sapiens) [TaxId:9606] [102152] (3 PDB entries)
    Uniprot Q99714
    1. Domain for 1so8:
    2. Domains for 1u7t:
      1. 820678Domain d1u7ta_: 1u7t A: [113099]
      2. 820679Domain d1u7tb_: 1u7t B: [113100]
      3. 820680Domain d1u7tc_: 1u7t C: [113101]
      4. 820681Domain d1u7td_: 1u7t D: [113102]
        complexed with nad, tdt; mutant
    3. Domains for 2o23:
      1. 820675Domain d2o23a1: 2o23 A:6-253 [138884]
        automatically matched to d1so8a_
        complexed with gol, nad
      2. 820676Domain d2o23b1: 2o23 B:6-253 [138885]
        automatically matched to d1so8a_
        complexed with gol, nad
  2. 820682Rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
    1. Domains for 1e3s:
      1. 820687Domain d1e3sa_: 1e3s A: [59201]
      2. 820688Domain d1e3sb_: 1e3s B: [59202]
      3. 820689Domain d1e3sc_: 1e3s C: [59203]
      4. 820690Domain d1e3sd_: 1e3s D: [59204]
        complexed with nad
    2. Domains for 1e3w:
      1. 820691Domain d1e3wa_: 1e3w A: [59207]
        CASP4
      2. 820692Domain d1e3wb_: 1e3w B: [59208]
        CASP4
      3. 820693Domain d1e3wc_: 1e3w C: [59209]
        CASP4
      4. 820694Domain d1e3wd_: 1e3w D: [59210]
        CASP4
        complexed with aae, nad, so4, trs
    3. Domains for 1e6w:
      1. 820683Domain d1e6wa_: 1e6w A: [59326]
      2. 820684Domain d1e6wb_: 1e6w B: [59327]
      3. 820685Domain d1e6wc_: 1e6w C: [59328]
      4. 820686Domain d1e6wd_: 1e6w D: [59329]
        complexed with est, nad
  3. 820695Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)

More info for Protein Type II 3-hydroxyacyl-CoA dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Type II 3-hydroxyacyl-CoA dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases: