SCOPe 2.08: Protein: Type II 3-hydroxyacyl-CoA dehydrogenase

Lineage for Protein: Type II 3-hydroxyacyl-CoA dehydrogenase

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (73 proteins)
also known as short-chain dehydrogenases and SDR family
parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
has additional subdomain(s) that are not in the common domain

Protein Type II 3-hydroxyacyl-CoA dehydrogenase [63933] (3 species)

Species:

Human (Homo sapiens) [TaxId:9606] [102152] (2 PDB entries)
Uniprot Q99714
1. Domain for 1so8:
  - Domain d1so8a_: 1so8 A: [98940]
    complexed with cl, na
2. Domains for 1u7t:
  1. Domain d1u7ta_: 1u7t A: [113099]
    complexed with nad, tdt
  2. Domain d1u7tb_: 1u7t B: [113100]
    complexed with nad, tdt
  3. Domain d1u7tc_: 1u7t C: [113101]
    complexed with nad, tdt
  4. Domain d1u7td_: 1u7t D: [113102]
    complexed with nad, tdt
Norway rat (Rattus norvegicus) [TaxId:10116] [63934] (3 PDB entries)
1. Domains for 1e3s:
  1. Domain d1e3sa_: 1e3s A: [59201]
    complexed with nad
  2. Domain d1e3sb_: 1e3s B: [59202]
    complexed with nad
  3. Domain d1e3sc_: 1e3s C: [59203]
    complexed with nad
  4. Domain d1e3sd_: 1e3s D: [59204]
    complexed with nad
2. Domains for 1e3w:
  1. Domain d1e3wa_: 1e3w A: [59207]
    CASP4
    complexed with aae, nad, so4, trs
  2. Domain d1e3wb_: 1e3w B: [59208]
    CASP4
    complexed with aae, nad, so4, trs
  3. Domain d1e3wc_: 1e3w C: [59209]
    CASP4
    complexed with aae, nad, so4, trs
  4. Domain d1e3wd_: 1e3w D: [59210]
    CASP4
    complexed with aae, nad, so4, trs
3. Domains for 1e6w:
  1. Domain d1e6wa_: 1e6w A: [59326]
    complexed with est, nad
  2. Domain d1e6wb_: 1e6w B: [59327]
    complexed with est, nad
  3. Domain d1e6wc_: 1e6w C: [59328]
    complexed with est, nad
  4. Domain d1e6wd_: 1e6w D: [59329]
    complexed with est, nad
Thermus thermophilus [TaxId:274] [89525] (1 PDB entry)
- Domains for 1uay:
  1. Domain d1uaya_: 1uay A: [88390]
    complexed with adn
  2. Domain d1uayb_: 1uay B: [88391]
    complexed with adn

More info for Protein Type II 3-hydroxyacyl-CoA dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases

Timeline for Protein Type II 3-hydroxyacyl-CoA dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases:

Protein Type II 3-hydroxyacyl-CoA dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases first appeared in SCOP 1.57, called Protein 3-hydroxyacyl-CoA dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases
Protein Type II 3-hydroxyacyl-CoA dehydrogenase from c.2.1.2: Tyrosine-dependent oxidoreductases appears in SCOPe 2.07