SCOPe 2.06: Species: Human (Homo sapiens) [TaxId: 9606]

Root: SCOPe 2.06
Class a: All alpha proteins [46456] (289 folds)
Fold a.26: 4-helical cytokines [47265] (1 superfamily)
core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections
Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
there are two different topoisomers of this fold with different entanglements of the two crossover connections
Family a.26.1.1: Long-chain cytokines [47267] (10 proteins)
Protein Heterodimeric interleukin-12 alpha chain [63530] (1 species)
Species Human (Homo sapiens) [TaxId:9606] [63531] (1 PDB entry)

Domain(s) for 1f45:
- Domain d1f45b_: 1f45 B: [59642]
  Other proteins in same PDB: d1f45a1, d1f45a2, d1f45a3

Timeline for Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Heterodimeric interleukin-12 alpha chain:

Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Heterodimeric interleukin-12 alpha chain first appeared in SCOP 1.57
Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Heterodimeric interleukin-12 alpha chain appears in SCOPe 2.05
Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Heterodimeric interleukin-12 alpha chain appears in SCOPe 2.07
Species Human (Homo sapiens) [TaxId:9606] from a.26.1.1 Heterodimeric interleukin-12 alpha chain appears in the current release, SCOPe 2.08