SCOP 1.69: Family a.4.5.28: MarR-like transcriptional regulators

Lineage for Family a.4.5.28: MarR-like transcriptional regulators

1. Root: SCOP 1.69

2. Class a: All alpha proteins [46456] (218 folds)

3. Fold a.4: DNA/RNA-binding 3-helical bundle [46688] (13 superfamilies)
   core: 3-helices; bundle, closed or partly opened, right-handed twist; up-and down

4. Superfamily a.4.5: "Winged helix" DNA-binding domain [46785] (55 families)
   contains a small beta-sheet (wing)

5. Family a.4.5.28: MarR-like transcriptional regulators [63379] (8 proteins)
   The N- and C-terminal helical extensions to the common fold form the dimer interface

Proteins:

1. Hypothetical protein PH1061 [101014] (1 species)

   • Species Archaeon Pyrococcus horikoshii [TaxId:53953] [101015] (1 PDB entry)

2. MexR repressor [81686] (1 species)

   • Species Pseudomonas aeruginosa [TaxId:287] [81687] (1 PDB entry)

3. Multiple antibiotic resistance repressor, MarR [68970] (1 species)

   • Species Escherichia coli [TaxId:562] [68971] (1 PDB entry)

4. Pleiotropic regulator of virulence genes, SarA [48292] (1 species)
   closely related to SarR but adopts a different fold; possible experimental artifact?

   • Species Staphylococcus aureus [TaxId:1280] [48293] (1 PDB entry)

5. Putative transcriptional regulator YusO [101012] (1 species)

   • Species Bacillus subtilis [TaxId:1423] [101013] (1 PDB entry)

6. Staphylococcal accessory regulator A homolog, SarR [63472] (1 species)

   • Species Staphylococcus aureus [TaxId:1280] [63473] (1 PDB entry)

7. Staphylococcal accessory regulator A homolog, SarS [88977] (1 species)
   duplication: tandem repeat of two SarR-like domains assembled together as in the SarR dimer

   • Species Staphylococcus aureus [TaxId:1280] [88978] (1 PDB entry)

8. Transcriptional regulator SlyA [81688] (1 species)

   • Species Enterococcus faecalis [TaxId:1351] [81689] (1 PDB entry)

More info for Family a.4.5.28: MarR-like transcriptional regulators

Timeline for Family a.4.5.28: MarR-like transcriptional regulators:

• Family a.4.5.28: MarR-like transcriptional regulators first appeared in SCOP 1.57
  
• Family a.4.5.28: MarR-like transcriptional regulators appears in SCOP 1.67
  
• Family a.4.5.28: MarR-like transcriptional regulators appears in SCOP 1.71
  
• Family a.4.5.28: MarR-like transcriptional regulators appears in the current release, SCOPe 2.08