SCOPe 2.07: Domain d1ju6d_: 1ju6 D:

Lineage for d1ju6d_ (1ju6 D:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families)
   automatically mapped to Pfam PF00303

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

6. Protein Thymidylate synthase [55833] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55840] (42 PDB entries)

8. Domain d1ju6d_: 1ju6 D: [63292]
   complexed with lya, po4, ump

Details for d1ju6d_

PDB Entry: 1ju6, 2.89 Å

PDB Description: human thymidylate synthase complex with dump and ly231514, a pyrrolo(2,3-d)pyrimidine-based antifolate

PDB Compounds: (D:) Thymidylate synthase

SCOPe Domain Sequences for d1ju6d_:

Sequence; same for both SEQRES and ATOM records:

>d1ju6d_ d.117.1.1 (D:) Thymidylate synthase {Human (Homo sapiens) [TaxId: 9606]}
hgelqylgqiqhilrcgvekddrtgtgtlsvfgmqaryslrdefpllttkrvfwkgvlee
llwfikgstnakelsskgvkiwdangsrdfldslgfstreegdlgpvygfqwrhfgaeyr
dmesdysgqgvdqlqrvidtiktnpddrriimcawnprdlplmalppchalcqfyvvnse
lscqlyqrsgdmglgvpfniasyalltymiahitglkpgdfihtlgdahiylnhieplki
qlqreprpfpklrilrkvekiddfkaedfqiegynphptikmemav

Timeline for d1ju6d_:

• d1ju6d_ first appeared in SCOP 1.57
  
• d1ju6d_ appears in SCOPe 2.06
  
• d1ju6d_ appears in the current release, SCOPe 2.08