SCOP 1.69: Domain d1jr1b1: 1jr1 B:11-112,B:233-514

Lineage for d1jr1b1 (1jr1 B:11-112,B:233-514)

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (31 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (1 family)
   The phosphate moiety of substrate binds in the 'common' phosphate-binding site

5. Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)

6. Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (6 species)

7. Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [63902] (1 PDB entry)

8. Domain d1jr1b1: 1jr1 B:11-112,B:233-514 [63244]
   Other proteins in same PDB: d1jr1a2, d1jr1a3
   contains two CBS domains inserted into the common fold, residues 113-232

Details for d1jr1b1

PDB Entry: 1jr1, 2.6 Å

PDB Description: crystal structure of inosine monophosphate dehydrogenase in complex with mycophenolic acid

SCOP Domain Sequences for d1jr1b1:

Sequence, based on SEQRES records:

>d1jr1b1 c.1.5.1 (B:11-112,B:233-514) Inosine monophosphate dehydrogenase (IMPDH) {Chinese hamster (Cricetulus griseus)}
syvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvsspm
dtvteagmaiamaltggigfihhnctpefqanevrkvkkyeqXyplaskdakkqllcgaa
igtheddkyrldllalagvdvvvldssqgnsifqinmikymkekypnlqviggnvvtaaq
aknlidagvdalrvgmgcgsicitqevlacgrpqatavykvseyarrfgvpviadggiqn
vghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldamdkhlssqnr
yfseadkikvaqgvsgavqdkgsihkfvpyliagiqhscqdigaksltqvrammysgelk
fekrtssaqveggvhslhsyekrlf

Sequence, based on observed residues (ATOM records):

>d1jr1b1 c.1.5.1 (B:11-112,B:233-514) Inosine monophosphate dehydrogenase (IMPDH) {Chinese hamster (Cricetulus griseus)}
syvpddgltaqqlfncgdgltyndflilpgyidftadqvdltsaltkkitlktplvsspm
dtvteagmaiamaltggigfihhnctpefqanevrkvkkyeqXyplaskdakkqllcgaa
igtheddkyrldllalagvdvvvldssqgnsifqinmikymkekypnlqviggnvvtaaq
aknlidagvdalrvgmgcgsicitqevlacgrpqatavykvseyarrfgvpviadggiqn
vghiakalalgastvmmgsllaatteapgeyffsdgirlkkyrgmgsldamikvaqgvsg
avqdkgsihkfvpyliagiqhscqdigaksltqvrammysgelkfekrtssaqveggvhs
lhsyekrlf

Timeline for d1jr1b1:

• d1jr1b1 first appeared in SCOP 1.57
  
• d1jr1b1 appears in SCOP 1.67
  
• d1jr1b1 appears in SCOP 1.71
  
• d1jr1b1 appears in the current release, SCOPe 2.08