SCOPe 2.06: Domain d1iapa_: 1iap A:

Lineage for d1iapa_ (1iap A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.91: Regulator of G-protein signaling, RGS [48096] (1 superfamily)
   multihelical; consists of two all-alpha subdomains
   contains a 4-helical bundle with left-handed twist and up-and-down topology

4. Superfamily a.91.1: Regulator of G-protein signaling, RGS [48097] (2 families)

5. Family a.91.1.1: Regulator of G-protein signaling, RGS [48098] (10 proteins)

6. Protein p115RhoGEF [63584] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63585] (1 PDB entry)

8. Domain d1iapa_: 1iap A: [62119]
   N-terminal RGS domain

Details for d1iapa_

PDB Entry: 1iap, 1.9 Å

PDB Description: crystal structure of p115rhogef rgrgs domain

PDB Compounds: (A:) guanine nucleotide exchange factor p115rhogef

SCOPe Domain Sequences for d1iapa_:

Sequence; same for both SEQRES and ATOM records:

>d1iapa_ a.91.1.1 (A:) p115RhoGEF {Human (Homo sapiens) [TaxId: 9606]}
sqfqsleqvkrrpahlmallqhvalqfepgpllcclhadmlgslgpkeakkafldfyhsf
lektavlrvpvppnvafeldrtradlisedvqrrfvqevvqsqqvavgrqledfrskrlm
gmtpweqelaqleawvgrdrasyearerhvaerllmhleemqhtistdeeksaavvnaig
lymrhlgvrt

Timeline for d1iapa_:

• d1iapa_ first appeared in SCOP 1.57
  
• d1iapa_ appears in SCOPe 2.05
  
• d1iapa_ appears in SCOPe 2.07
  
• d1iapa_ appears in the current release, SCOPe 2.08